Open AccessDeletion of IL-6 Exacerbates Colitis and Induces Systemic Inflammation in IL-10-Deficient Mice
Author(s) -
Mei Ye,
Maria E. Joosse,
Ling Liu,
Yu Sun,
Ying Dong,
Chen Cai,
Zhen-Mei Song,
Jennifer Zhang,
Steven R. Brant,
Mark Lazarev,
Xuhang Li
Publication year - 2019
Publication title -
journal of crohn's and colitis
Language(s) - English
Resource type - Journals
eISSN - 1876-4479
pISSN - 1873-9946
DOI - 10.1093/ecco-jcc/jjz176
Subject(s) - neutrophilia , foxp3 , inflammation , immunology , medicine , inflammatory bowel disease , mesenteric lymph nodes , interleukin , interleukin 17 , colitis , monocytosis , systemic inflammation , intestinal mucosa , cytokine , disease , immune system , bone marrow
Interleukin 6 [IL-6] or its receptor is currently a candidate for targeted biological therapy of inflammatory bowel disease [IBD]. Thus, a comprehensive understanding of the consequences of blocking IL-6 is imperative. We investigated this by evaluating the effects of IL-6 deletion on the spontaneous colitis of IL-10-deficient mice [IL-10-/-].