Adverse Events and Nocebo Effects in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Zendy

Christopher Ma | Zendy; Nicola Panaccione | Zendy; Tran M Nguyen | Zendy; Leonardo Guizzetti | Zendy; Claire E. Parker | Zendy; Isra M. Hussein | Zendy; Niels Vande Casteele | Zendy; Reena Khanna | Zendy; Parambir S. Dulai | Zendy; Siddharth Singh | Zendy; Brian G. Feagan | Zendy; Vipul Jairath | Zendy

Open Access

Adverse Events and Nocebo Effects in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Author(s) -

Christopher Ma,

Nicola Panaccione,

Tran M Nguyen,

Leonardo Guizzetti,

Claire E. Parker,

Isra M. Hussein,

Niels Vande Casteele,

Reena Khanna,

Parambir S. Dulai,

Siddharth Singh,

Brian G. Feagan,

Vipul Jairath

Publication year - 2019

Publication title -

journal of crohn s and colitis

Language(s) - English

Resource type - Journals

eISSN - 1876-4479

pISSN - 1873-9946

DOI - 10.1093/ecco-jcc/jjz087

Subject(s) - medicine , randomized controlled trial , adverse effect , placebo , meta analysis , ulcerative colitis , inflammatory bowel disease , relative risk , crohn's disease , confidence interval , gastroenterology , disease , pathology , alternative medicine

Nocebo effects, adverse outcomes occurring in patients receiving inert therapy, contribute to adverse event [AE] reporting in randomized controlled trials [RCTs]. High placebo AE rates may result in inaccurate estimation of treatment-related AEs. We estimate the pooled rate of AEs in patients randomized to placebo compared to active therapy in inflammatory bowel disease [IBD] RCTs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research