Ciclosporin Therapy After Infliximab Failure in Hospitalized Patients With Acute Severe Colitis is Effective and Safe | Zendy

Roni Weisshof | Zendy; Jacob E. Ollech | Zendy; Katia El Jurdi | Zendy; Olivia Yvellez | Zendy; Russell D. Cohen | Zendy; Atsushi Sakuraba | Zendy; Sushila Dalal | Zendy; Joel Pekow | Zendy; David T. Rubin | Zendy

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Ciclosporin Therapy After Infliximab Failure in Hospitalized Patients With Acute Severe Colitis is Effective and Safe

Author(s) -

Roni Weisshof,

Jacob E. Ollech,

Katia El Jurdi,

Olivia Yvellez,

Russell D. Cohen,

Atsushi Sakuraba,

Sushila Dalal,

Joel Pekow,

David T. Rubin

Publication year - 2019

Publication title -

journal of crohn s and colitis

Language(s) - English

Resource type - Journals

eISSN - 1876-4479

pISSN - 1873-9946

DOI - 10.1093/ecco-jcc/jjz032

Subject(s) - medicine , infliximab , ciclosporin , adverse effect , discontinuation , rescue therapy , interquartile range , colectomy , refractory (planetary science) , surgery , ulcerative colitis , colitis , gastroenterology , transplantation , physics , disease , astrobiology

Options for medical management of patients with acute severe colitis [ASC] failing intravenous (i.v.) steroids are limited and include rescue therapy with either infliximab or ciclosporin. In patients failing infliximab, second-line rescue therapy with ciclosporin is an alternative. The aim of this study was to investigate the efficacy and safety of ciclosporin in patients with steroid-refractory ASC failing first-line rescue therapy with infliximab.

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