Open AccessTranscriptome-Wide Association Study for Inflammatory Bowel Disease Reveals Novel Candidate Susceptibility Genes in Specific Colon Subsites and Tissue Categories
Author(s) -
Virginia Díez-Obrero,
Ferran MoratallaNavarro,
Gemma IbáñezSanz,
Jordi Guardiola,
Francisco Rodríguez-Moranta,
Mireia ObónSantacana,
Anna Díez-Villanueva,
Christopher H. Dampier,
Matthew A.M. Devall,
Robert CarrerasTorres,
Graham Casey,
Vı́ctor Moreno
Publication year - 2021
Publication title -
journal of crohn's and colitis
Language(s) - English
Resource type - Journals
eISSN - 1876-4479
pISSN - 1873-9946
DOI - 10.1093/ecco-jcc/jjab131
Subject(s) - genome wide association study , transcriptome , candidate gene , biology , genetic association , genetic architecture , gene , inflammatory bowel disease , genetics , disease , computational biology , genetic predisposition , gene expression , genotype , single nucleotide polymorphism , phenotype , medicine , pathology
Genome-wide association studies [GWAS] for inflammatory bowel disease [IBD] have identified 240 risk variants. However, the benefit of understanding the genetic architecture of IBD remains to be exploited. Transcriptome-wide association studies [TWAS] associate gene expression with genetic susceptibility to disease, providing functional insight into risk loci. In this study, we integrate relevant datasets for IBD and perform a TWAS to nominate novel genes implicated in IBD genetic susceptibility.