Open AccessPotential Role of Epithelial Endoplasmic Reticulum Stress and Anterior Gradient Protein 2 Homologue in Crohn’s Disease Fibrosis
Author(s) -
Sophie Vieujean,
Shurong Hu,
Emeline Bequet,
Catherine Salée,
Charlotte Massot,
Noëlla Blétard,
Nicolas Pierre,
Florence Quesada Calvo,
Dominique Baiwir,
Gabriel Mazzucchelli,
Edwin De Pauw,
Carla Coimbra Marques,
Philippe Delvenne,
Florian Rieder,
Édouard Louis,
MarieAlice Meuwis
Publication year - 2021
Publication title -
journal of crohn's and colitis
Language(s) - English
Resource type - Journals
eISSN - 1876-4479
pISSN - 1873-9946
DOI - 10.1093/ecco-jcc/jjab061
Subject(s) - endoplasmic reticulum , unfolded protein response , tunicamycin , myofibroblast , secretion , extracellular matrix , epithelium , biology , immunohistochemistry , laser capture microdissection , pathology , fibroblast , secretory protein , microbiology and biotechnology , fibrosis , immunology , medicine , endocrinology , in vitro , biochemistry , gene expression , gene
Intestinal fibrosis is a common complication of Crohn's disease [CD]. It is characterised by an accumulation of fibroblasts differentiating into myofibroblasts secreting excessive extracellular matrix. The potential role of the intestinal epithelium in this fibrotic process remains poorly defined.