Open AccessOverexpression of Vitamin D Receptor in Intestinal Epithelia Protects Against Colitis via Upregulating Tight Junction Protein Claudin 15
Author(s) -
Ishita Chatterjee,
Yongguo Zhang,
Jilei Zhang,
Rong Lü,
Yinglin Xia,
Jun Sun
Publication year - 2021
Publication title -
journal of crohn's and colitis
Language(s) - English
Resource type - Journals
eISSN - 1876-4479
pISSN - 1873-9946
DOI - 10.1093/ecco-jcc/jjab044
Subject(s) - calcitriol receptor , claudin , tight junction , colitis , downregulation and upregulation , intestinal mucosa , barrier function , endocrinology , calcitriol , medicine , receptor , chemistry , cancer research , biology , vitamin d and neurology , microbiology and biotechnology , biochemistry , gene
Dysfunction of the vitamin D receptor [VDR] contributes to the aetiology of IBD by regulating autophagy, immune response, and mucosal permeability. VDR directly controls the paracellular tight junction protein Claudin-2. Claudin-2 and Claudin-15 are unique in maintaining paracellular permeability. Interestingly, claudin-15 mRNA was downregulated in patients with ulcerative colitis. However, the exact mechanism of Claudin-15 regulation in colitis is still unknown. Here, we investigated the protective role of VDR against intestinal inflammation via upregulating Claudin-15.