Open AccessCannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis
Author(s) -
William Becker,
Haider Rasheed Alrafas,
Philip Brandon Busbee,
Michael D. Walla,
Kiesha Wilson,
Kathryn Miranda,
Guoshuai Cai,
Vasanta Putluri,
Nagireddy Putluri,
Mitzi Nagarkatti
Publication year - 2020
Publication title -
journal of crohn's and colitis
Language(s) - English
Resource type - Journals
eISSN - 1876-4479
pISSN - 1873-9946
DOI - 10.1093/ecco-jcc/jjaa253
Subject(s) - colitis , haematopoiesis , immune system , inflammatory bowel disease , cannabinoid receptor , inflammation , cannabinoid , immunology , cannabinoid receptor type 2 , pharmacology , biology , receptor , medicine , stem cell , microbiology and biotechnology , disease , agonist
Cannabinoid receptor [CB] activation can attenuate inflammatory bowel disease [IBD] in experimental models and human cohorts. However, the roles of the microbiome, metabolome, and the respective contributions of haematopoietic and non-haematopoietic cells in the anti-colitic effects of cannabinoids have yet to be determined.