Open AccessDynamics of the Stool Virome in Very Early-Onset Inflammatory Bowel Disease
Author(s) -
Guanxiang Liang,
Máire A. Conrad,
Judith R. Kelsen,
Lyanna Kessler,
Jessica Breton,
Lindsey Albenberg,
Sarah Marakos,
Alissa Galgano,
Nina Devas,
Jessi Erlichman,
Huanjia Zhang,
Lisa M. Mattei,
Kyle Bittinger,
Robert N. Baldassano,
Frederic D. Bushman
Publication year - 2020
Publication title -
journal of crohn's and colitis
Language(s) - English
Resource type - Journals
eISSN - 1876-4479
pISSN - 1873-9946
DOI - 10.1093/ecco-jcc/jjaa094
Subject(s) - human virome , dysbiosis , inflammatory bowel disease , immunology , microbiome , disease , virus , biomarker , pathogenesis , biology , virology , gut flora , medicine , metagenomics , genetics , gene
Dysbiosis of the gut microbiota is a well-known correlate of the pathogenesis of inflammatory bowel disease [IBD]. However, few studies have examined the microbiome in very early-onset [VEO] IBD, which is defined as onset of IBD before 6 years of age. Here we focus on the viral portion of the microbiome-the virome-to assess possible viral associations with disease processes, reasoning that any viruses potentially associated with IBD might grow more robustly in younger subjects, and so be more detectable.