Assignment of Human Membrane-type Matrix Metalloproteinase-2 (MT2-MMP) Gene to 16q12 by FISH and PCR-based Human/Rodent Cell Hybrid Mapping Panel Analysis | Zendy

Hidetaro Yasumitsu | Zendy

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Assignment of Human Membrane-type Matrix Metalloproteinase-2 (MT2-MMP) Gene to 16q12 by FISH and PCR-based Human/Rodent Cell Hybrid Mapping Panel Analysis

Author(s) -

Hidetaro Yasumitsu

Publication year - 1997

Publication title -

dna research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.647

H-Index - 98

eISSN - 1756-1663

pISSN - 1340-2838

DOI - 10.1093/dnares/4.1.77

Subject(s) - biology , matrix metalloproteinase , complementary dna , gene , fluorescence in situ hybridization , microbiology and biotechnology , in situ hybridization , genetics , gene mapping , cdna library , gene expression , chromosome

A new group of matrix metalloproteinase with a potential membrane domain was reported as membrane-type matrix metalloproteinases (MT-MMPs), and the gene coding for one of them, MT2-MMP was recently cloned from a human lung cDNA library. To predict its physiological functions by the relation to the genetic disorders mapped on the chromosomes, the chromosomal location of the human MT2-MMP gene was examined by fluorescence in situ hybridization (FISH) and PCR-based analysis with human/rodent hybrid cell mapping panels, and it was assigned to 16q12.

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