Open AccessOUP accepted manuscript
Author(s) -
Sachin Gavali,
Julie Cowart,
Chuming Chen,
Karen Ross,
Cecilia N. Arighi,
Cathy Wu
Publication year - 2020
Publication title -
database
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.406
H-Index - 62
ISSN - 1758-0463
DOI - 10.1093/database/baz157
Subject(s) - computer science , python (programming language) , world wide web , cloud computing , software , data science , software engineering , programming language , operating system
iPTMnet is a bioinformatics resource that integrates protein post-translational modification (PTM) data from text mining and curated databases and ontologies to aid in knowledge discovery and scientific study. The current iPTMnet website can be used for querying and browsing rich PTM information but does not support automated iPTMnet data integration with other tools. Hence, we have developed a RESTful API utilizing the latest developments in cloud technologies to facilitate the integration of iPTMnet into existing tools and pipelines. We have packaged iPTMnet API software in Docker containers and published it on DockerHub for easy redistribution. We have also developed Python and R packages that allow users to integrate iPTMnet for scientific discovery, as demonstrated in a use case that connects PTM sites to kinase signaling pathways.