Open AccessShort-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine γ-lyase
Author(s) -
Kaspar Trocha,
Peter Kip,
Ming Tao,
Michael R. MacArthur,
J. Humberto Treviño-Villarreal,
Alban Longchamp,
Wendy Toussaint,
Bart N. Lambrecht,
Margreet R. de Vries,
Paul H.A. Quax,
James R. Mitchell,
C. Keith Ozaki
Publication year - 2019
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvz086
Subject(s) - cystathionine beta synthase , cystathionine gamma lyase , medicine , endocrinology , surgery , biochemistry , biology , enzyme , cysteine
Therapies to prevent vein graft disease, a major problem in cardiovascular and lower extremity bypass surgeries, are currently lacking. Short-term preoperative protein restriction holds promise as an effective preconditioning method against surgical stress in rodent models, but whether it can improve vein graft patency after bypass surgery is undetermined. Here, we hypothesized that short-term protein restriction would limit vein graft disease via up-regulation of cystathionine γ-lyase and increased endogenous production of the cytoprotective gaseous signalling molecule hydrogen sulfide.