Open AccessActivating P2Y1 receptors improves function in arteries with repressed autophagy
Author(s) -
Jae Min Cho,
SeulKi Park,
Oh Sung Kwon,
D. Taylor La Salle,
James Cerbie,
Caitlin C. Fermoyle,
David Morgan,
Ashley D. Nelson,
Amber D. Bledsoe,
Leena P. Bharath,
Megan Tandar,
Satya P. Kunapuli,
Russell S. Richardson,
Pon Velayutham Anandh Babu,
Sohom Mookherjee,
Bellamkonda Kishore,
Fei Wang,
Tianxin Yang,
Sihem Boudina,
Joel D. Trinity,
J. David Symons
Publication year - 2022
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvac061
Subject(s) - autophagy , medicine , endocrinology , nitric oxide synthase , vasodilation , vascular smooth muscle , biology , nitric oxide , biochemistry , apoptosis , smooth muscle
The importance of endothelial cell (EC) autophagy to vascular homeostasis in the context of health and disease is evolving. Earlier, we reported that intact EC autophagy is requisite to maintain shear-stress-induced nitric oxide (NO) generation via glycolysis-dependent purinergic signalling to endothelial NO synthase (eNOS). Here, we illustrate the translational and functional significance of these findings.