Open AccessPannexin 1: a novel regulator of acute hypoxic pulmonary vasoconstriction
Author(s) -
Benjamin Grimmer,
Adrienn Krauszman,
Xudong Hu,
Golam Kabir,
Kim A. Connelly,
Mei Li,
Jana Grune,
Christian Madry,
Brant E. Isakson,
Wolfgang M. Kuebler
Publication year - 2021
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvab326
Subject(s) - hypoxic pulmonary vasoconstriction , purinergic receptor , hypoxia (environmental) , vasoconstriction , pannexin , biology , p2y receptor , microbiology and biotechnology , receptor , vascular smooth muscle , medicine , pulmonary hypertension , endocrinology , pharmacology , chemistry , intracellular , extracellular , gap junction , biochemistry , connexin , organic chemistry , oxygen , smooth muscle
Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to alveolar hypoxia that diverts blood flow from poorly ventilated to better aerated lung areas to optimize ventilation-perfusion matching. Yet, the exact sensory and signalling mechanisms by which hypoxia triggers pulmonary vasoconstriction remain incompletely understood. Recently, ATP release via pannexin 1 (Panx1) and subsequent signalling via purinergic P2Y receptors has been identified as regulator of vasoconstriction in systemic arterioles. Here, we probed for the role of Panx1-mediated ATP release in HPV and chronic hypoxic pulmonary hypertension (PH).