Open AccessNatriuretic peptide receptor B maintains heart rate and sinoatrial node function via cyclic GMP-mediated signalling
Author(s) -
Tristan W. Dorey,
Martin Mackasey,
Hailey J. Jansen,
Megan D. McRae,
Loryn J. Bohne,
Yingjie Liu,
Darrell D. Belke,
Logan Atkinson,
Robert A. Rose
Publication year - 2021
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvab245
Subject(s) - medicine , ibmx , endocrinology , phosphodiesterase 3 , sinoatrial node , phosphodiesterase , natriuretic peptide , myocyte , atrial natriuretic peptide , receptor , second messenger system , npr2 , chemistry , heart rate , forskolin , heart failure , biochemistry , enzyme , blood pressure
Heart rate (HR) is a critical indicator of cardiac performance that is determined by sinoatrial node (SAN) function and regulation. Natriuretic peptides, including C-type NP (CNP), have been shown to modulate ion channel function in the SAN when applied exogenously. CNP is the only NP that acts as a ligand for natriuretic peptide receptor-B (NPR-B). Despite these properties, the ability of CNP and NPR-B to regulate HR and intrinsic SAN automaticity in vivo, and the mechanisms by which it does so, are incompletely understood. Thus, the objective of this study was to determine the role of NPR-B signalling in regulating HR and SAN function.