Epidermal growth factor receptor-dependent maintenance of cardiac contractility | Zendy

Shuchi Guo | Zendy; Ama Dedo Okyere | Zendy; Erin McEachern | Zendy; Joshua Strong | Zendy; Rhonda L. Carter | Zendy; Viren Patwa | Zendy; Toby P. Thomas | Zendy; Melissa Landy | Zendy; Jianliang Song | Zendy; Ana Maria Lucchese | Zendy; Thomas G. Martin | Zendy; Erhe Gao | Zendy; Sudarsan Rajan | Zendy; Jonathan A. Kirk | Zendy; Walter J. Koch | Zendy; Joseph Y. Cheung | Zendy; Douglas G. Tilley | Zendy

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Epidermal growth factor receptor-dependent maintenance of cardiac contractility

Author(s) -

Shuchi Guo,

Ama Dedo Okyere,

Erin McEachern,

Joshua Strong,

Rhonda L. Carter,

Viren Patwa,

Toby P. Thomas,

Melissa Landy,

Jianliang Song,

Ana Maria Lucchese,

Thomas G. Martin,

Erhe Gao,

Sudarsan Rajan,

Jonathan A. Kirk,

Walter J. Koch,

Joseph Y. Cheung,

Douglas G. Tilley

Publication year - 2021

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvab149

Subject(s) - contractility , epidermal growth factor receptor , medicine , receptor , cardiology , endocrinology , biology

Epidermal growth factor receptor (EGFR) is essential to the development of multiple tissues and organs and is a target of cancer therapeutics. Due to the embryonic lethality of global EGFR deletion and conflicting reports of cardiac-overexpressed EGFR mutants, its specific impact on the adult heart, normally or in response to chronic stress, has not been established. Using complimentary genetic strategies to modulate cardiomyocyte-specific EGFR expression, we aim to define its role in the regulation of cardiac function and remodelling.

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