Open AccessEpidermal growth factor receptor-dependent maintenance of cardiac contractility
Author(s) -
Shuchi Guo,
Ama Dedo Okyere,
Erin McEachern,
Joshua Strong,
Rhonda L. Carter,
Viren Patwa,
Toby P. Thomas,
Melissa Landy,
Jianliang Song,
Ana Maria Lucchese,
Thomas G. Martin,
Erhe Gao,
Sudarsan Rajan,
Jonathan A. Kirk,
Walter J. Koch,
Joseph Y. Cheung,
Douglas G. Tilley
Publication year - 2021
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvab149
Subject(s) - downregulation and upregulation , epidermal growth factor receptor , phospholamban , contractility , endocrinology , medicine , biology , nfat , epidermal growth factor , heart failure , receptor , calcineurin , transplantation , biochemistry , gene
Epidermal growth factor receptor (EGFR) is essential to the development of multiple tissues and organs and is a target of cancer therapeutics. Due to the embryonic lethality of global EGFR deletion and conflicting reports of cardiac-overexpressed EGFR mutants, its specific impact on the adult heart, normally or in response to chronic stress, has not been established. Using complimentary genetic strategies to modulate cardiomyocyte-specific EGFR expression, we aim to define its role in the regulation of cardiac function and remodelling.