Arrhythmogenesis in the aged heart following ischaemia–reperfusion: role of transient receptor potential vanilloid 4 | Zendy

Deborah Peana | Zendy; Luis PoloParada | Zendy; Timothy L. Domeier | Zendy

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Arrhythmogenesis in the aged heart following ischaemia–reperfusion: role of transient receptor potential vanilloid 4

Author(s) -

Deborah Peana,

Luis PoloParada,

Timothy L. Domeier

Publication year - 2021

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvab141

Subject(s) - transient receptor potential channel , medicine , cardiology , diastole , membrane potential , trpv4 , endocrinology , myocyte , homeostasis , receptor , biology , biophysics , blood pressure

Cardiomyocyte Ca2+ homoeostasis is altered with ageing and predisposes the heart to Ca2+ intolerance and arrhythmia. Transient receptor potential vanilloid 4 (TRPV4) is an osmotically activated cation channel with expression in cardiomyocytes of the aged heart. The objective of this study was to examine the role of TRPV4 in Ca2+ handling and arrhythmogenesis following ischaemia-reperfusion (I/R), a pathological scenario associated with osmotic stress.

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