Open AccessArrhythmogenesis in the aged heart following ischaemia–reperfusion: role of transient receptor potential vanilloid 4
Author(s) -
Deborah Peana,
Luis PoloParada,
Timothy L. Domeier
Publication year - 2021
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvab141
Subject(s) - transient receptor potential channel , medicine , cardiology , diastole , membrane potential , trpv4 , endocrinology , myocyte , chemistry , receptor , blood pressure , biochemistry
Cardiomyocyte Ca2+ homoeostasis is altered with ageing and predisposes the heart to Ca2+ intolerance and arrhythmia. Transient receptor potential vanilloid 4 (TRPV4) is an osmotically activated cation channel with expression in cardiomyocytes of the aged heart. The objective of this study was to examine the role of TRPV4 in Ca2+ handling and arrhythmogenesis following ischaemia-reperfusion (I/R), a pathological scenario associated with osmotic stress.