Open AccessImpaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension
Author(s) -
Zhichao Sheng,
Hua Zhang,
Peiru Zheng,
Shanyan Chen,
Zezong Gu,
Jingjing Zhou,
J. Glenn Phaup,
Hui-Ming Chang,
Edward T.H. Yeh,
HuiLin Pan,
De-Pei Li
Publication year - 2021
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvab031
Subject(s) - rostral ventrolateral medulla , microinjection , medicine , endocrinology , medulla oblongata , sympathetic nervous system , central nucleus of the amygdala , potassium channel , blood pressure , brainstem , chemistry , amygdala , central nervous system
Elevated sympathetic outflow is associated with primary hypertension. However, the mechanisms involved in heightened sympathetic outflow in hypertension are unclear. The central amygdala (CeA) regulates autonomic components of emotions through projections to the brainstem. The neuronal Kv7 channel is a non-inactivating voltage-dependent K+ channel encoded by KCNQ2/3 genes involved in stabilizing the neuronal membrane potential and regulating neuronal excitability. In this study, we investigated if altered Kv7 channel activity in the CeA contributes to heightened sympathetic outflow in hypertension.