Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension | Zendy

ZhaoFu Sheng | Zendy; Hua Zhang | Zendy; Peiru Zheng | Zendy; Shanyan Chen | Zendy; Zezong Gu | Zendy; Jingjing Zhou | Zendy; J. Glenn Phaup | Zendy; HuiMing Chang | Zendy; Edward T.H. Yeh | Zendy; HuiLin Pan | Zendy; DePei Li | Zendy

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Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension

Author(s) -

ZhaoFu Sheng,

Hua Zhang,

Peiru Zheng,

Shanyan Chen,

Zezong Gu,

Jingjing Zhou,

J. Glenn Phaup,

HuiMing Chang,

Edward T.H. Yeh,

HuiLin Pan,

DePei Li

Publication year - 2021

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvab031

Subject(s) - rostral ventrolateral medulla , microinjection , medicine , endocrinology , medulla oblongata , sympathetic nervous system , central nucleus of the amygdala , potassium channel , blood pressure , chemistry , amygdala , central nervous system

Elevated sympathetic outflow is associated with primary hypertension. However, the mechanisms involved in heightened sympathetic outflow in hypertension are unclear. The central amygdala (CeA) regulates autonomic components of emotions through projections to the brainstem. The neuronal Kv7 channel is a non-inactivating voltage-dependent K+ channel encoded by KCNQ2/3 genes involved in stabilizing the neuronal membrane potential and regulating neuronal excitability. In this study, we investigated if altered Kv7 channel activity in the CeA contributes to heightened sympathetic outflow in hypertension.

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