Open AccessDietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure
Author(s) -
Michinari Nakamura,
Natalija Odanović,
Yasuki Nakada,
Satomi Dohi,
Peiyong Zhai,
Andreas S. Ivessa,
Zhi Yang,
Maha Abdellatif,
Junichi Sadoshima
Publication year - 2020
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvaa298
Subject(s) - pressure overload , medicine , endocrinology , muscle hypertrophy , heart failure , ketone bodies , biology , cardiac hypertrophy , metabolism
A diet with modified components, such as a ketogenic low-carbohydrate (LC) diet, potentially extends longevity and healthspan. However, how an LC diet impacts on cardiac pathology during haemodynamic stress remains elusive. This study evaluated the effects of an LC diet high in either fat (Fat-LC) or protein (Pro-LC) in a mouse model of chronic hypertensive cardiac remodelling.