Open AccessCo-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events
Author(s) -
Sara Ballouz,
Melissa Mangala,
Matthew D. Perry,
Stewart Heitmann,
Jesse Gillis,
Adam P. Hill,
Jamie I. Vandenberg
Publication year - 2020
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvaa280
Subject(s) - herg , afterdepolarization , potassium channel , ion channel , gene expression , induced pluripotent stem cell , in silico , cardiac action potential , biology , medicine , repolarization , pharmacology , endocrinology , gene , electrophysiology , genetics , receptor , embryonic stem cell
Cardiac electrical activity is extraordinarily robust. However, when it goes wrong it can have fatal consequences. Electrical activity in the heart is controlled by the carefully orchestrated activity of more than a dozen different ion conductances. While there is considerable variability in cardiac ion channel expression levels between individuals, studies in rodents have indicated that there are modules of ion channels whose expression co-vary. The aim of this study was to investigate whether meta-analytic co-expression analysis of large-scale gene expression datasets could identify modules of co-expressed cardiac ion channel genes in human hearts that are of functional importance.