Open AccessCardiac cellularity is dependent upon biological sex and is regulated by gonadal hormones
Author(s) -
Galen T Squiers,
Micheal A. McLellan,
Alexei Ilinykh,
Jane Branca,
Nadia Rosenthal,
Alexander R. Pinto
Publication year - 2020
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvaa265
Subject(s) - hormone , biology , testosterone (patch) , cardiac myocyte , endocrine system , endocrinology , medicine , cardiovascular physiology , myocyte , cell type , cell physiology , physiology , cell , genetics
Sex differences have been consistently identified in cardiac physiology and incidence of cardiac disease. However, the underlying biological causes for the differences remain unclear. We sought to characterize the cardiac non-myocyte cellular landscape in female and male hearts to determine whether cellular proportion of the heart is sex-dependent and whether endocrine factors modulate the cardiac cell proportions.