Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction | Zendy

Zeina R. Al Sayed | Zendy; Robin Canac | Zendy; Bastien Cimarosti | Zendy; Carine Bonnard | Zendy; JeanBaptiste Gourraud | Zendy; Hanan Hamamy | Zendy; Hülya Kayserili | Zendy; Aurore Girardeau | Zendy; Mariam Jouni | Zendy; Nicolas Jacob | Zendy; Anne Gaignerie | Zendy; Caroline Chariau | Zendy; Laurent David | Zendy; Virginie Forest | Zendy; Céline Marionneau | Zendy; Flavien Charpentier | Zendy; Gildas Loussouarn | Zendy; Guillaume Lamirault | Zendy; Bruno Reversade | Zendy; Kazem Zibara | Zendy; Patricia Lemarchand | Zendy; Nathalie Gaborit | Zendy

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Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction

Author(s) -

Zeina R. Al Sayed,

Robin Canac,

Bastien Cimarosti,

Carine Bonnard,

JeanBaptiste Gourraud,

Hanan Hamamy,

Hülya Kayserili,

Aurore Girardeau,

Mariam Jouni,

Nicolas Jacob,

Anne Gaignerie,

Caroline Chariau,

Laurent David,

Virginie Forest,

Céline Marionneau,

Flavien Charpentier,

Gildas Loussouarn,

Guillaume Lamirault,

Bruno Reversade,

Kazem Zibara,

Patricia Lemarchand,

Nathalie Gaborit

Publication year - 2020

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvaa259

Subject(s) - biology , depolarization , transcription factor , cardiac electrophysiology , homeobox , sodium channel , medicine , endocrinology , microbiology and biotechnology , electrophysiology , neuroscience , genetics , gene , chemistry , sodium , organic chemistry

Several inherited arrhythmic diseases have been linked to single gene mutations in cardiac ion channels and interacting proteins. However, the mechanisms underlying most arrhythmias, are thought to involve altered regulation of the expression of multiple effectors. In this study, we aimed to examine the role of a transcription factor (TF) belonging to the Iroquois homeobox family, IRX5, in cardiac electrical function.

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