Open AccessRole of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis
Author(s) -
Bhupesh Singla,
Hui Ping Lin,
Alex Chen,
WonMo Ahn,
Pushpankur Ghoshal,
Mary CherianShaw,
Joseph White,
Brian K. Stansfield,
Gábor Csányi
Publication year - 2020
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvaa244
Subject(s) - lymphangiogenesis , biology , cancer research , lrp6 , medicine , endocrinology , microbiology and biotechnology , wnt signaling pathway , signal transduction , cancer , metastasis
Impaired lymphatic drainage of the arterial wall results in intimal lipid accumulation and atherosclerosis. However, the mechanisms regulating lymphangiogenesis in atherosclerotic arteries are not well understood. Our studies identified elevated levels of matrix protein R-spondin 2 (RSPO2) in atherosclerotic arteries. In this study, we investigated the role of RSPO2 in lymphangiogenesis, arterial cholesterol efflux into lesion-draining lymph nodes (LNs) and development of atherosclerosis.