Open AccessThe glycocalyx core protein Glypican 1 protects vessel wall endothelial cells from stiffness-mediated dysfunction and disease
Author(s) -
Marwa Mahmoud,
Mariya Mayer,
Limary M. Cancel,
Anne Marie W. Bartosch,
Rick Mathews,
John M. Tarbell
Publication year - 2020
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvaa201
Subject(s) - glycocalyx , endothelial dysfunction , endothelial stem cell , microbiology and biotechnology , endothelium , inflammation , arterial stiffness , medicine , chemistry , immunology , biology , biochemistry , in vitro , blood pressure
Arterial stiffness is an underlying risk factor and a hallmark of cardiovascular diseases. The endothelial cell (EC) glycocalyx is a glycan rich surface layer that plays a key role in protecting against EC dysfunction and vascular disease. However, the mechanisms by which arterial stiffness promotes EC dysfunction and vascular disease are not fully understood, and whether the mechanism involves the protective endothelial glycocalyx is yet to be determined. We hypothesized that endothelial glycocalyx protects the endothelial cells lining the vascular wall from dysfunction and disease in response to arterial stiffness.