Open AccessKetones can become the major fuel source for the heart but do not increase cardiac efficiency
Author(s) -
Kim L. Ho,
Qutuba G. Karwi,
Cory S. Wagg,
Liyan Zhang,
Katherina Vo,
Tariq Altamimi,
Golam Mezbah Uddin,
John R. Ussher
Publication year - 2020
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvaa143
Subject(s) - ketone bodies , ketone , beta oxidation , citric acid cycle , medicine , fatty acid , chemistry , cardiac function curve , endocrinology , metabolism , biochemistry , biology , heart failure , organic chemistry
Ketones have been proposed to be a 'thrifty' fuel for the heart and increasing cardiac ketone oxidation can be cardioprotective. However, it is unclear how much ketone oxidation can contribute to energy production in the heart, nor whether increasing ketone oxidation increases cardiac efficiency. Therefore, our goal was to determine to what extent high levels of the ketone body, β-hydroxybutyrate (βOHB), contributes to cardiac energy production, and whether this influences cardiac efficiency.