Open AccessThe impact of patient sex on the response to intramyocardial mesenchymal stem cell administration in patients with non-ischaemic dilated cardiomyopathy
Author(s) -
Victoria Florea,
Angela C. Rieger,
Makoto Natsumeda,
Bryon A. Tompkins,
Monisha N. Banerjee,
Ivonne Hernandez Schulman,
Courtney Premer,
Aisha Khan,
Krystalenia Valasaki,
Bettina Heidecker,
Alejandro Mantero,
Wayne Balkan,
Raul D. Mitrani
Publication year - 2020
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvaa004
Subject(s) - medicine , ejection fraction , stem cell therapy , heart failure , dilated cardiomyopathy , mesenchymal stem cell , cardiology , cardiomyopathy , stem cell , pathology , biology , genetics
Sex differences impact the occurrence, presentation, prognosis, and response to therapy in heart disease. Particularly, the phenotypic presentation of patients with non-ischaemic dilated cardiomyopathy (NIDCM) differs between men and women. However, whether the response to mesenchymal stem cell (MSC) therapy is influenced by sex remains unknown. We hypothesize that males and females with NIDCM respond similarly to MSC therapy.