Open AccessChronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery
Author(s) -
Kimberly N. Weaver,
Bharati Kochar,
Jonathan J. Hansen,
Kim L. Isaacs,
Animesh Jain,
Shehzad Z. Sheikh,
Alessandro Fichera,
Nicole Chaumont,
Tim Sadiq,
Mark J. Koruda,
Millie D. Long,
Hans Herfarth,
Edward L. Barnes
Publication year - 2019
Publication title -
crohn's and colitis 360
Language(s) - English
Resource type - Journals
ISSN - 2631-827X
DOI - 10.1093/crocol/otz029
Subject(s) - pouchitis , pouch , anastomosis , medicine , surgery , surgical anastomosis , antibiotics , ulcerative colitis , biology , microbiology and biotechnology , disease
Background Risk factors for the development of chronic antibiotic dependent pouchitis (CADP) are not well understood. Methods Using multivariable logistic regression, we compared clinical factors between 194 patients with acute antibiotic responsive pouchitis or CADP. Results Individuals with CADP were significantly older (40.9 vs 30.8 years, P < 0.001) and demonstrated a longer disease duration before IPAA (10.3 vs 7.0 years, P = 0.004). Age ≥55 years at the time of IPAA was significantly associated with CADP (adjusted odds ratio = 4.35, 95% confidence interval = 1.01–18.7). Conclusions Although older age should not represent a barrier to IPAA, further studies evaluating etiologies of this association are warranted.