Safety, Tolerability, and Immunogenicity of Plasmodium falciparum Sporozoite Vaccine Administered by Direct Venous Inoculation to Infants and Young Children: Findings From an Age De-escalation, Dose-Escalation, Double-blind, Randomized Controlled Study in Western Kenya | Zendy

Laura C. Steinhardt | Zendy; Thomas L. Richie | Zendy; Reuben Yego | Zendy; Dorcas Akach | Zendy; Mary J. Hamel | Zendy; Julie Gutman | Zendy; Ryan E. Wiegand | Zendy; Elizabeth L. Nzuu | Zendy; Allan Dungani | Zendy; Natasha KC | Zendy; Tooba Murshedkar | Zendy; L. W. Preston Church | Zendy; B. Kim Lee Sim | Zendy; Peter F. Billingsley | Zendy; Eric R. James | Zendy; Yonas Abebe | Zendy; Simon Kariuki | Zendy; Aaron M. Samuels | Zendy; Kephas Otieno | Zendy; Tony Sang | Zendy; S. Patrick Kachur | Zendy; David Styers | Zendy; Kelly Schlessman | Zendy; Ginnie Abarbanell | Zendy; Stephen L. Hoffman | Zendy; Robert A. Seder | Zendy; Martina Oneko | Zendy

Open Access

Safety, Tolerability, and Immunogenicity of Plasmodium falciparum Sporozoite Vaccine Administered by Direct Venous Inoculation to Infants and Young Children: Findings From an Age De-escalation, Dose-Escalation, Double-blind, Randomized Controlled Study in Western Kenya

Author(s) -

Laura C. Steinhardt,

Thomas L. Richie,

Reuben Yego,

Dorcas Akach,

Mary J. Hamel,

Julie Gutman,

Ryan E. Wiegand,

Elizabeth L. Nzuu,

Allan Dungani,

Natasha KC,

Tooba Murshedkar,

L. W. Preston Church,

B. Kim Lee Sim,

Peter F. Billingsley,

Eric R. James,

Yonas Abebe,

Simon Kariuki,

Aaron M. Samuels,

Kephas Otieno,

Tony Sang,

S. Patrick Kachur,

David Styers,

Kelly Schlessman,

Ginnie Abarbanell,

Stephen L. Hoffman,

Robert A. Seder,

Martina Oneko

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz925

Subject(s) - medicine , tolerability , adverse effect , placebo , immunogenicity , vaccination , plasmodium falciparum , randomized controlled trial , malaria vaccine , malaria , immunology , antibody , alternative medicine , pathology

The whole Plasmodium falciparum sporozoite (PfSPZ) vaccine is being evaluated for malaria prevention. The vaccine is administered intravenously for maximal efficacy. Direct venous inoculation (DVI) with PfSPZ vaccine has been safe, tolerable, and feasible in adults, but safety data for children and infants are limited.

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