A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis | Zendy

Shruthi Ravimohan | Zendy; Pholo Maenetje | Zendy; Sara C. Auld | Zendy; Itai Ncube | Zendy; Mandla Mlotshwa | Zendy; W Chase | Zendy; Caroline T. Tiemessen | Zendy; Mboyo-Di-Tamba Vangu | Zendy; Robert S. Wallis | Zendy; Gavin Churchyard | Zendy; Drew Weissman | Zendy; Hardy Kornfeld | Zendy; Gregory P. Bisson | Zendy

Open Access

A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis

Author(s) -

Shruthi Ravimohan,

Pholo Maenetje,

Sara C. Auld,

Itai Ncube,

Mandla Mlotshwa,

W Chase,

Caroline T. Tiemessen,

Mboyo-Di-Tamba Vangu,

Robert S. Wallis,

Gavin Churchyard,

Drew Weissman,

Hardy Kornfeld,

Gregory P. Bisson

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz898

Subject(s) - vital capacity , medicine , single nucleotide polymorphism , inflammasome , immunology , inflammation , snp , pulmonary function testing , prospective cohort study , genotype , lung , biology , gene , lung function , genetics , diffusing capacity

Inflammasomes mediate inflammation in adults living with both human immunodeficiency virus (HIV) and tuberculosis (TB), but the relevance of inflammasome gene polymorphisms in TB-associated pulmonary damage is unknown. We hypothesized that functional single-nucleotide polymorphisms (SNPs) in inflammasome pathway genes modify systemic and pulmonary inflammation, contributing to respiratory impairment in adults living with HIV/pulmonary TB.

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