Open AccessA Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis
Author(s) -
Shruthi Ravimohan,
Pholo Maenetje,
Sara C. Auld,
Itai Ncube,
Mandla Mlotshwa,
William H. Chase,
Caroline T. Tiemessen,
Mboyo-Di-Tamba Vangu,
Robert S. Wallis,
Gavin Churchyard,
Drew Weissman,
Hardy Kornfeld,
Gregory P. Bisson
Publication year - 2019
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciz898
Subject(s) - vital capacity , medicine , single nucleotide polymorphism , inflammasome , immunology , inflammation , snp , pulmonary function testing , prospective cohort study , genotype , lung , biology , gene , lung function , genetics , diffusing capacity
Inflammasomes mediate inflammation in adults living with both human immunodeficiency virus (HIV) and tuberculosis (TB), but the relevance of inflammasome gene polymorphisms in TB-associated pulmonary damage is unknown. We hypothesized that functional single-nucleotide polymorphisms (SNPs) in inflammasome pathway genes modify systemic and pulmonary inflammation, contributing to respiratory impairment in adults living with HIV/pulmonary TB.