Open AccessClinical and Epidemiological Aspects of Diphtheria: A Systematic Review and Pooled Analysis
Author(s) -
Shaun Truelove,
Lindsay T Keegan,
William J. Moss,
Lelia H. Chaisson,
E Macher,
Andrew S. Azman,
Justin Lessler
Publication year - 2019
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciz808
Subject(s) - diphtheria , medicine , outbreak , vaccination , pediatrics , carriage , epidemiology , diphtheria toxin , transmission (telecommunications) , corynebacterium diphtheriae , confidence interval , immunology , virology , biology , microbiology and biotechnology , pathology , electrical engineering , toxin , engineering
Diphtheria, once a major cause of childhood morbidity and mortality, all but disappeared following introduction of diphtheria vaccine. Recent outbreaks highlight the risk diphtheria poses when civil unrest interrupts vaccination and healthcare access. Lack of interest over the last century resulted in knowledge gaps about diphtheria's epidemiology, transmission, and control.