Open AccessPredicted Effectiveness of Daily and Nondaily Preexposure Prophylaxis for Men Who Have Sex With Men Based on Sex and Pill-taking Patterns From the Human Immuno Virus Prevention Trials Network 067/ADAPT Study
Author(s) -
Dobromir Dimitrov,
James R. Moore,
Daniel Wood,
Kate Mitchell,
Maoji Li,
James P. Hughes,
Deborah Donnell,
Sharon Mannheimer,
Timothy H. Holtz,
Robert M. Grant,
Marie-Claude Boily
Publication year - 2019
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciz799
Subject(s) - men who have sex with men , pre exposure prophylaxis , dosing , pill , medicine , human immunodeficiency virus (hiv) , demography , incidence (geometry) , family medicine , pharmacology , physics , syphilis , sociology , optics
The HIV Prevention Trials Network (HPTN) 067/Alternative Dosing to Augment PrEP Pill Taking (ADAPT) Study evaluated the feasibility of daily and nondaily human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) regimens among high-risk populations, including men who have sex with men (MSM) and transgender women, in Bangkok, Thailand and Harlem, New York. We used a mathematical model to predict the efficacy and effectiveness of different dosing regimens.