Molecular Approach to Diagnosis of Cardiovascular Implantable Electronic Device Infection | Zendy

Zerelda Esquer Garrigos | Zendy; M. Rizwan Sohail | Zendy; Kerryl E. GreenwoodQuaintance | Zendy; Scott A. Cunningham | Zendy; Prakhar Vijayvargiya | Zendy; Madiha Fida | Zendy; Paul A. Friedman | Zendy; Jayawant N. Mandrekar | Zendy; Daniel C. DeSimone | Zendy; Larry M. Baddour | Zendy; Robin Patel | Zendy

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Molecular Approach to Diagnosis of Cardiovascular Implantable Electronic Device Infection

Author(s) -

Zerelda Esquer Garrigos,

M. Rizwan Sohail,

Kerryl E. GreenwoodQuaintance,

Scott A. Cunningham,

Prakhar Vijayvargiya,

Madiha Fida,

Paul A. Friedman,

Jayawant N. Mandrekar,

Daniel C. DeSimone,

Larry M. Baddour,

Robin Patel

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz266

Subject(s) - medicine , cardiology , intensive care medicine

Sonicate fluid (SF), a solution derived from vortexing and sonication of explanted cardiovascular implantable electronic devices (CIEDs), is a higher-yield specimen compared with swabs or tissues for culture-based detection of microorganisms associated with CIED infection. Despite this, SF culture fails to identify a causative organism in ~50% of cases. We aimed to evaluate the diagnostic performance of 16S ribosomal RNA gene (rRNA) polymerase chain reaction (PCR)/sequencing of SF and compare it with that of SF culture.

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