Open AccessBlood Transcriptomic Stratification of Short-term Risk in Contacts of Tuberculosis
Author(s) -
Jennifer Roe,
Cristina Venturini,
Gupta Rk,
Céline Gurry,
Benjamin M. Chain,
Yuxin Sun,
Jo Southern,
Charlotte Jackson,
Marc Lipman,
R F Miller,
Adrian R. Martineau,
Ibrahim Abubakar,
Mahdad Noursadeghi
Publication year - 2019
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciz252
Subject(s) - tuberculosis , medicine , mycobacterium tuberculosis , cohort , subclinical infection , immunology , cohort study , disease , asymptomatic , prospective cohort study , pathology
The highest risk of tuberculosis arises in the first few months after exposure. We reasoned that this risk reflects incipient disease among tuberculosis contacts. Blood transcriptional biomarkers of tuberculosis may predate clinical diagnosis, suggesting they offer improved sensitivity to detect subclinical incipient disease. Therefore, we sought to test the hypothesis that refined blood transcriptional biomarkers of active tuberculosis will improve stratification of short-term disease risk in tuberculosis contacts.