Blood Transcriptomic Stratification of Short-term Risk in Contacts of Tuberculosis | Zendy

Jennifer Roe | Zendy; Cristina Venturini | Zendy; Rishi K Gupta | Zendy; Céline Gurry | Zendy; Benny Chain | Zendy; Yuxin Sun | Zendy; Jo Southern | Zendy; Charlotte Jackson | Zendy; Marc Lipman | Zendy; Robert F. Miller | Zendy; Adrian R. Martineau | Zendy; Ibrahim Abubakar | Zendy; Mahdad Noursadeghi | Zendy

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Blood Transcriptomic Stratification of Short-term Risk in Contacts of Tuberculosis

Author(s) -

Jennifer Roe,

Cristina Venturini,

Rishi K Gupta,

Céline Gurry,

Benny Chain,

Yuxin Sun,

Jo Southern,

Charlotte Jackson,

Marc Lipman,

Robert F. Miller,

Adrian R. Martineau,

Ibrahim Abubakar,

Mahdad Noursadeghi

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciz252

Subject(s) - medicine , risk stratification , tuberculosis , stratification (seeds) , term (time) , pathology , biology , seed dormancy , botany , germination , physics , quantum mechanics , dormancy

The highest risk of tuberculosis arises in the first few months after exposure. We reasoned that this risk reflects incipient disease among tuberculosis contacts. Blood transcriptional biomarkers of tuberculosis may predate clinical diagnosis, suggesting they offer improved sensitivity to detect subclinical incipient disease. Therefore, we sought to test the hypothesis that refined blood transcriptional biomarkers of active tuberculosis will improve stratification of short-term disease risk in tuberculosis contacts.

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