Adenovirus-Based Vaccines and Thrombosis in Pregnancy: A Systematic Review and Meta-analysis | Zendy

Lauren Pischel | Zendy; Kavin M. Patel | Zendy; George Goshua | Zendy; Saad B. Omer | Zendy

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Adenovirus-Based Vaccines and Thrombosis in Pregnancy: A Systematic Review and Meta-analysis

Author(s) -

Lauren Pischel,

Kavin M. Patel,

George Goshua,

Saad B. Omer

Publication year - 2022

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciac080

Subject(s) - medicine , meta analysis , pregnancy , thrombosis , medline , virology , immunology , obstetrics , genetics , biology , political science , law

Rare cases of thrombosis and thrombocytopenia (thrombosis with thrombocytopenia syndrome [TTS]) have been associated with 2 coronavirus disease 2019 adenovirus vector vaccines: the ChAdOx1 nCoV-19 Vaxzevria vaccine (Oxford/AstraZeneca) and the JNJ-7836735 Johnson & Johnson vaccine (Janssen). It is unknown if TTS is a class-mediated effect of adenovirus-based vaccines or if it could worsen known hypercoagulable states. Since most cases of TTS happen in women of childbearing age, pregnancy is a crucial risk factor to assess. Understanding these risks is important for advising vaccine recipients and future adenovirus vector vaccine development.

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