Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons | Zendy

Jamin Liu | Zendy; Matthew T. Laurie | Zendy; Luis Rubio | Zendy; Sara E. Vazquez | Zendy; Sara Sunshine | Zendy; Anthea Mitchell | Zendy; Matthias Hapte-Selassie | Zendy; Sabrina A Mann | Zendy; Genay Pilarowski | Zendy; Douglas Black | Zendy; Carina Marquez | Zendy; Susana Rojas | Zendy; Michail S. Lionakis | Zendy; Maya Petersen | Zendy; Jeffrey D. Whitman | Zendy; Vivek Jain | Zendy; Mark S. Anderson | Zendy; Diane V. Havlir | Zendy; Joseph L. DeRisi | Zendy

Open Access

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons

Author(s) -

Jamin Liu,

Matthew T. Laurie,

Luis Rubio,

Sara E. Vazquez,

Sara Sunshine,

Anthea Mitchell,

Matthias Hapte-Selassie,

Sabrina A Mann,

Genay Pilarowski,

Douglas Black,

Carina Marquez,

Susana Rojas,

Michail S. Lionakis,

Maya Petersen,

Jeffrey D. Whitman,

Vivek Jain,

Mark S. Anderson,

Diane V. Havlir,

Joseph L. DeRisi

Publication year - 2022

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciac029

Subject(s) - medicine , transmission (telecommunications) , immunology , immunity , covid-19 , immune system , coronavirus , autoimmunity , disease , virology , vaccination , infectious disease (medical specialty) , outbreak , electrical engineering , engineering

While SARS-CoV-2 vaccines prevent severe disease effectively, postvaccination “breakthrough” COVID-19 infections and transmission among vaccinated individuals remain ongoing concerns. We present an in-depth characterization of transmission and immunity among vaccinated individuals in a household, revealing complex dynamics and unappreciated comorbidities, including autoimmunity to type 1 interferon in the presumptive index case.

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