Open AccessProgressive Development of Cefiderocol Resistance in Escherichia coli During Therapy is Associated With an Increase in blaNDM-5 Copy Number and Gene Expression
Author(s) -
Patricia J. Simner,
Heba H. Mostafa,
Yehudit Bergman,
Michael Ante,
Tsigereda Tekle,
Ayomikun Adebayo,
Stephan Beisken,
Kathryn Dzintars,
Pranita D. Tamma
Publication year - 2021
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciab888
Subject(s) - aztreonam , escherichia coli , biology , plasmid , gene , microbiology and biotechnology , ceftazidime , pseudomonas aeruginosa , genetics , bacteria
As cefiderocol is increasingly being prescribed in clinical practice, it is critical that we understand key mechanisms contributing to acquired resistance to this agent.