Open AccessDiscrimination and Calibration of the Veterans Aging Cohort Study Index 2.0 for Predicting Mortality Among People With Human Immunodeficiency Virus in North America
Author(s) -
Kathleen McGinnis,
Amy C. Justice,
Richard D. Moore,
Michael J. Silverberg,
Keri N. Althoff,
Maile Y. Karris,
Viviane D. Lima,
Heidi M. Crane,
Michael A. Horberg,
Marina B. Klein,
Stephen J. Gange,
Kelly A. Gebo,
Angel M. Mayor,
Janet P. Tate,
Constance A. Benson,
Ronald J. Bosch,
Gregory D. Kirk,
Vincent C. Marconi,
Jonathan Colasanti,
Kenneth H. Mayer,
Chris Grasso,
Robert S. Hogg,
Viviane D. Lima,
Julio S. G. Montaner,
Paul Sereda,
Kate Salters,
Kate Buchacz,
Jun Li,
Kelly A. Gebo,
Richard D. Moore,
Richard D. Moore,
Jeffrey M. Jacobson,
Michael A. Horberg,
Michael J. Silverberg,
Jennifer E. Thorne,
Todd T. Brown,
Phyllis C. Tien,
Gypsyamber D’Souza,
Graham Smith,
Mona Loutfy,
Manisha Gupta,
Marina B. Klein,
Charles S. Rabkin,
Abigail Kroch,
Ann Burchell,
Adrian Betts,
Joanne Lindsay,
Ank E. Nijhawan,
Angel M. Mayor,
M John Gill,
Jeffrey N. Martin,
Jun Li,
John T. Brooks,
Michael S. Saag,
Michael J. Mugavero,
James H. Willig,
Laura Bamford,
Maile Y. Karris,
Joseph J. Eron,
Sonia Napravnik,
Mari M. Kitahata,
Heidi M. Crane,
Timothy R. Sterling,
David W. Haas,
Peter F. Rebeiro,
Megan Turner,
Kathleen McGinnis,
Amy C. Justice,
Richard D. Moore,
Keri N. Althoff,
Stephen J. Gange,
Mari M. Kitahata,
Jennifer S. Lee,
Michael S. Saag,
Michael A. Horberg,
Marina B. Klein,
Rosemary G. McKaig,
Aimee Freeman,
Richard D. Moore,
Keri N. Althoff,
Aimee Freeman,
Mari M. Kitahata,
Stephen E. Van Rompaey,
Heidi M. Crane,
Liz Morton,
Justin McReynolds,
William B. Lober,
Stephen J. Gange,
Jennifer S. Lee,
Brenna Hogan,
Bin You,
Elizabeth Humes,
Lucas Gerace,
Cameron Stewart,
Sally B. Coburn
Publication year - 2021
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciab883
Subject(s) - medicine , cohort , confidence interval , demography , cohort study , human immunodeficiency virus (hiv) , mortality rate , statistic , ethnic group , national death index , gerontology , statistics , hazard ratio , immunology , mathematics , sociology , anthropology
The updated Veterans Aging Cohort Study (VACS) Index 2.0 combines general and human immunodeficiency virus (HIV)-specific biomarkers to generate a continuous score that accurately discriminates risk of mortality in diverse cohorts of persons with HIV (PWH), but a score alone is difficult to interpret. Using data from the North American AIDS Cohort Collaboration (NA-ACCORD), we translate VACS Index 2.0 scores into validated probability estimates of mortality.