Open AccessUltrasensitive and Quantitative Toxin Measurement Correlates With Baseline Severity, Severe Outcomes, and Recurrence Among Hospitalized Patients With Clostridioides difficile Infection
Author(s) -
Carolyn D. Alonso,
Ciarán P. Kelly,
Kevin W. Garey,
Anne J Gonzales-Luna,
David N. Williams,
Kaitlyn Daugherty,
Christine Cuddemi,
Javier Villafuerte-Gálvez,
Nicole White,
Xinhua Chen,
Hua Xu,
Rebecca Sprague,
Caitlin Barrett,
Mark A. Miller,
Agnès Foussadier,
Aude Lantz,
Alice Banz,
Nira R. Pollock
Publication year - 2021
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciab826
Subject(s) - medicine , interquartile range , clostridioides , gastroenterology , toxin , feces , clostridium difficile toxin a , diarrhea , clostridium difficile , antibiotics , microbiology and biotechnology , biology
Stool toxin concentrations may impact Clostridioides difficile infection (CDI) severity and outcomes. We correlated fecal C difficile toxin concentrations, measured by an ultrasensitive and quantitative assay, with CDI baseline severity, attributable outcomes, and recurrence.