Open AccessCongenital Human Cytomegalovirus Infection Is Associated With Decreased Transplacental IgG Transfer Efficiency Due to Maternal Hypergammaglobulinemia
Author(s) -
Eleanor C Semmes,
Shuk Hang Li,
Jillian H. Hurst,
Zidanyue Yang,
Doniedzwiecki,
Genevieve G. Fouda,
Joanne Kurtzberg,
Kyle M. Walsh,
Sallie R. Permar
Publication year - 2021
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciab627
Subject(s) - transplacental , medicine , hypergammaglobulinemia , immunology , immunoglobulin g , pregnancy , antibody , fetus , biology , placenta , genetics
Placentally transferred maternal immunoglobulin G (IgG) protects against pathogens in early life, yet vertically transmitted infections can interfere with transplacental IgG transfer. Although human cytomegalovirus (HCMV) is the most common placentally-transmitted viral infection worldwide, the impact of congenital HCMV (cCMV) infection on transplacental IgG transfer has been underexplored.