Open AccessDetection of IFN-γ Secretion in Blood Samples Collected Before and After Treatment of Varying Stages of Lyme Disease
Author(s) -
Paul M. Arnaboldi,
Christina D’Arco,
Yosefa Hefter,
Sheila M. Nolan,
Dean A. Jobe,
Steven M. Callister,
Raymond J. Dattwyler
Publication year - 2021
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciab503
Subject(s) - medicine , lyme disease , borrelia burgdorferi , immunology , gastroenterology , lyme , antibody
QuantiFERON enzyme-linked immunosorbent assay (ELISA; Qiagen) with Borrelia burgdorferi peptide antigens was previously shown to reliably detect interferon-γ (IFN-γ) in blood samples from adult patients with early Lyme disease and the response disappeared rapidly after treatment. We evaluated the response before and after appropriate antibiotic therapy in adolescent and adult subjects with more diverse stages of the illness.