Open AccessPlasma Citrate and Succinate Are Associated With Neurocognitive Impairment in Older People With HIV.
Author(s) -
Corrilynn Olesky Hileman,
Robert C. Kalayjian,
Sausan Azzam,
Daniela Schlatzer,
Kun Wu,
Katherine Tassiopoulos,
Roger Bedimo,
Ronald J. Ellis,
Kristine M. Erlandson,
Asha Kallianpur,
Susan L. Koletar,
Alan Landay,
Frank J. Palella,
Babafemi Taiwo,
Muralidhar Pallaki,
Charles L. Hoppel
Publication year - 2021
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciab107
Subject(s) - neurocognitive , medicine , logistic regression , cohort , gait , endocrinology , physiology , cognition , psychiatry
Neurocognitive impairment (NCI) is associated with monocyte activation in people with HIV (PWH). Activated monocytes increase glycolysis, reduce oxidative phosphorylation, and accumulate citrate and succinate, tricarboxylic acid (TCA) cycle metabolites that promote inflammation-this metabolic shift may contribute to NCI and slowed gait speed in PWH.