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Hyperinflammatory Syndromes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Messenger RNA vaccination in Individuals With Underlying Immune Dysregulation
Author(s) -
Joseph M. Rocco,
Christina Mallarino-Haeger,
Attiya Randolph,
Susan M. Ray,
Marcos C. Schechter,
Christa S. Zerbe,
Steven M. Holland,
Irini Sereti
Publication year - 2021
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciab1024
Subject(s) - medicine , vaccination , immunology , immune system , immune dysregulation , coronavirus , covid-19 , disease , infectious disease (medical specialty)
The development of effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines has been a significant accomplishment. Adverse events are extremely rare, but continued surveillance is important, especially in at-risk populations. In 5 patients with preexisting immune dysregulation, hyperinflammatory syndromes, including hemophagocytic lymphohistiocytosis, developed after SARS-CoV-2 mRNA vaccination. Early recognition of this rare condition is essential.

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