Open AccessThe Immunoglobulin M-Shed Acute Phase Antigen (SAPA)-test for the Early Diagnosis of Congenital Chagas Disease in the Time of the Elimination Goal of Mother-to-Child Transmission
Author(s) -
Yagahira E. Castro-Sesquen,
Freddy Tinajeros,
Caryn Bern,
Gerson Galdos-Cardenas,
Edith Málaga,
Edward Valencia Ayala,
Kathryn A. Hjerrild,
Steven J. Clipman,
Andrés G. Lescano,
Tabitha Bayangos,
Walter Castillo,
María Carmen Menduiña,
Kawsar R. Talaat,
Robert H. Gilman,
Perú
Publication year - 2020
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciaa986
Subject(s) - medicine , chagas disease , cohort , antibody , immunology , antigen , trypanosoma cruzi , pediatrics , cohort study , parasite hosting , world wide web , computer science
Diagnosis of congenital Chagas disease (CChD) in most endemic areas is based on low-sensitive microscopy at birth and 9-month immunoglobulin G (IgG), which has poor adherence. We aim to evaluate the accuracy of the Immunoglobulin M (IgM)-Shed Acute Phase Antigen (SAPA) test in the diagnosis of CChD at birth.