Open AccessOutcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100–200 Cells/µL in Botswana
Author(s) -
Mark W Tenforde,
Thandi Milton,
Ikanyeng Rulaganyang,
Charles Muthoga,
Leabaneng Tawe,
Tom Chiller,
Gregory S. Greene,
Alexander Jordan,
Colin J. Williams,
Leah A. Owen,
Tshepo Leeme,
Amber Boose,
Julia Ngidi,
Madisa Mine,
Joseph N Jarvis
Publication year - 2020
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciaa899
Subject(s) - medicine , human immunodeficiency virus (hiv) , antigen , immunopathology , immunology , virology , sida , viral disease , virus , immunodeficiency , immune system
Increasing the CD4-count threshold for cryptococcal antigen (CrAg) screening from ≤100 to ≤200 cells/µL resulted in a 3-fold increase in numbers screened. CrAg-prevalence was 3.5% at CD4 101-200 and 6.2% ≤100 cells/µL. Six-month mortality was 21.4% (9/42) in CrAg-positive CD4 ≤100 cells/µL and 3.2% (1/31) in CrAg-positive CD4 101-200 cells/µL.