Open AccessAlterations of the Oral Microbiome and Cumulative Carbapenem Exposure Are Associated With Stenotrophomonas maltophilia Infection in Patients With Acute Myeloid Leukemia Receiving Chemotherapy
Author(s) -
Samuel L Aitken,
Pranoti Sahasrabhojane,
Dimitrios P. Kontoyiannis,
Tor Savidge,
César A. Arias,
Nadim J. Ajami,
Samuel A. Shelburne,
Jessica Galloway-Peña
Publication year - 2020
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciaa778
Subject(s) - stenotrophomonas maltophilia , medicine , myeloid leukemia , hazard ratio , pneumonia , meropenem , leukemia , gastroenterology , immunology , microbiology and biotechnology , antibiotics , confidence interval , pseudomonas aeruginosa , antibiotic resistance , biology , bacteria , genetics
Stenotrophomonas maltophilia is increasingly common in patients with acute myeloid leukemia (AML). Little is known about factors that drive S. maltophilia infection. We evaluated the microbiome and cumulative antibiotic use as predictors of S. maltophilia infection in AML patients receiving remission induction chemotherapy (RIC).