Open AccessLiver Fibrosis in Human Immunodeficiency Virus (HIV)-Hepatitis C Virus (HCV) Coinfection Before and After Sustained Virologic Response: What Is the Best Noninvasive Marker for Monitoring Regression?
Author(s) -
Nadine Kronfli,
James Young,
Shouao Wang,
Joseph Cox,
Sharon Walmsley,
Mark Hull,
Curtis Cooper,
Valérie Martel-Laferrière,
Alexander Wong,
Neora Pick,
Marina B. Klein
Publication year - 2020
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciaa702
Subject(s) - medicine , coinfection , hepatitis c virus , transient elastography , gastroenterology , hepatitis c , hepatocellular carcinoma , liver biopsy , fibrosis , cohort , ribavirin , immunology , biopsy , human immunodeficiency virus (hiv) , virus
Noninvasive markers of liver fibrosis such as aspartate aminotransferase-to-platelet ratio (APRI) and transient elastography (TE) have largely replaced liver biopsy for staging hepatitis C virus (HCV). As there is little longitudinal data, we compared changes in these markers before and after sustained virologic response (SVR) in human immunodeficiency virus (HIV)-HCV coinfected patients.