Resistance-Conferring Mutations on Whole-Genome Sequencing of Fluoroquinolone-resistant and -Susceptible Mycobacterium tuberculosis Isolates: A Proposed Threshold for Identifying Resistance | Zendy

Fernanda Maruri | Zendy; Yan Guo | Zendy; Amondrea Blackman | Zendy; Yuri F. van der Heijden | Zendy; Peter F. Rebeiro | Zendy; Timothy R. Sterling | Zendy

Open Access

Resistance-Conferring Mutations on Whole-Genome Sequencing of Fluoroquinolone-resistant and -Susceptible Mycobacterium tuberculosis Isolates: A Proposed Threshold for Identifying Resistance

Author(s) -

Fernanda Maruri,

Yan Guo,

Amondrea Blackman,

Yuri F. van der Heijden,

Peter F. Rebeiro,

Timothy R. Sterling

Publication year - 2020

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciaa496

Subject(s) - ofloxacin , dna gyrase , allele , allele frequency , mycobacterium tuberculosis , genetics , biology , mutation , tuberculosis , medicine , gene , antibiotics , ciprofloxacin , escherichia coli , pathology

Fluoroquinolone resistance in Mycobacterium tuberculosis (Mtb) is conferred by DNA gyrase mutations, but not all fluoroquinolone-resistant Mtb isolates have mutations detected. The optimal allele frequency threshold to identify resistance-conferring mutations by whole-genome sequencing is unknown.

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