Open AccessIntestinal Perforations Associated With a High Mortality and Frequent Complications During an Epidemic of Multidrug-resistant Typhoid Fever in Blantyre, Malawi
Author(s) -
Franziska Olgemoeller,
J Waluza,
Dalitso Zeka,
Jillian Gauld,
Peter J. Diggle,
Jonathan M. Read,
Thomas Edwards,
Chisomo Msefula,
Angeziwa Chirambo,
Melita A. Gordon,
Emma C. Thomson,
Robert S. Heyderman,
Eric Borgstein,
Nicholas Feasey
Publication year - 2020
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciaa405
Subject(s) - typhoid fever , medicine , perforation , salmonella typhi , bacteremia , surgery , mortality rate , case fatality rate , blood culture , prospective cohort study , epidemiology , context (archaeology) , pathology , microbiology and biotechnology , antibiotics , paleontology , biochemistry , chemistry , materials science , escherichia coli , biology , gene , punching , metallurgy
Typhoid fever remains a major source of morbidity and mortality in low-income settings. Its most feared complication is intestinal perforation. However, due to the paucity of diagnostic facilities in typhoid-endemic settings, including microbiology, histopathology, and radiology, the etiology of intestinal perforation is frequently assumed but rarely confirmed. This poses a challenge for accurately estimating burden of disease.