Intestinal Perforations Associated With a High Mortality and Frequent Complications During an Epidemic of Multidrug-resistant Typhoid Fever in Blantyre, Malawi | Zendy

Franziska Olgemoeller | Zendy; J Waluza | Zendy; Dalitso Zeka | Zendy; Jillian Gauld | Zendy; Peter J. Diggle | Zendy; Jonathan M. Read | Zendy; Thomas Edwards | Zendy; Chisomo Msefula | Zendy; Angeziwa Chunga Chirambo | Zendy; Melita A. Gordon | Zendy; Emma C. Thomson | Zendy; Robert S. Heyderman | Zendy; Eric Borgstein | Zendy; Nicholas Feasey | Zendy

Open Access

Intestinal Perforations Associated With a High Mortality and Frequent Complications During an Epidemic of Multidrug-resistant Typhoid Fever in Blantyre, Malawi

Author(s) -

Franziska Olgemoeller,

J Waluza,

Dalitso Zeka,

Jillian Gauld,

Peter J. Diggle,

Jonathan M. Read,

Thomas Edwards,

Chisomo Msefula,

Angeziwa Chunga Chirambo,

Melita A. Gordon,

Emma C. Thomson,

Robert S. Heyderman,

Eric Borgstein,

Nicholas Feasey

Publication year - 2020

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciaa405

Subject(s) - typhoid fever , multiple drug resistance , medicine , virology , biology , microbiology and biotechnology , drug resistance

Typhoid fever remains a major source of morbidity and mortality in low-income settings. Its most feared complication is intestinal perforation. However, due to the paucity of diagnostic facilities in typhoid-endemic settings, including microbiology, histopathology, and radiology, the etiology of intestinal perforation is frequently assumed but rarely confirmed. This poses a challenge for accurately estimating burden of disease.

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