Infant Exposure to Dolutegravir Through Placental and Breast Milk Transfer: A Population Pharmacokinetic Analysis of DolPHIN-1 | Zendy

Laura Dickinson | Zendy; Stephen Walimbwa | Zendy; Yashna Singh | Zendy; Julian Kaboggoza | Zendy; Kenneth Kintu | Zendy; Mary Sihlangu | Zendy; Julie-Anne Coombs | Zendy; Thokozile R. Malaba | Zendy; Josaphat Byamugisha | Zendy; Henry Pertinez | Zendy; Alieu Amara | Zendy; Joshua Gini | Zendy; Laura Else | Zendy; Christie Heiberg | Zendy; Eva Maria Hodel | Zendy; Helen Reynolds | Zendy; Landon Myer | Zendy; Catriona Waitt | Zendy; Saye Khoo | Zendy; Mohammed Lamorde | Zendy; Catherine Orrell | Zendy; Ritah Nakijoba | Zendy; Isabella Kyohairwe | Zendy; Johnson Magoola | Zendy; Emmanuel Ssempija | Zendy

Open Access

Infant Exposure to Dolutegravir Through Placental and Breast Milk Transfer: A Population Pharmacokinetic Analysis of DolPHIN-1

Author(s) -

Laura Dickinson,

Stephen Walimbwa,

Yashna Singh,

Julian Kaboggoza,

Kenneth Kintu,

Mary Sihlangu,

Julie-Anne Coombs,

Thokozile R. Malaba,

Josaphat Byamugisha,

Henry Pertinez,

Alieu Amara,

Joshua Gini,

Laura Else,

Christie Heiberg,

Eva Maria Hodel,

Helen Reynolds,

Landon Myer,

Catriona Waitt,

Saye Khoo,

Mohammed Lamorde,

Catherine Orrell,

Ritah Nakijoba,

Isabella Kyohairwe,

Johnson Magoola,

Emmanuel Ssempija

Publication year - 2020

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciaa1861

Subject(s) - dolutegravir , medicine , efavirenz , breast milk , obstetrics , population , pharmacokinetics , pregnancy , breast feeding , umbilical cord , pediatrics , viral load , antiretroviral therapy , human immunodeficiency virus (hiv) , immunology , biochemistry , chemistry , environmental health , biology , genetics

Rapid reduction in human immunodeficiency virus (HIV) load is paramount to prevent peripartum transmission in women diagnosed late in pregnancy. We investigated dolutegravir population pharmacokinetics in maternal plasma, umbilical cord, breast milk, and infant plasma samples from DolPHIN-1 participants (NCT02245022) presenting with untreated HIV late in pregnancy (28-36 weeks gestation).

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