Cefiderocol for the Treatment of Adult and Pediatric Patients With Cystic Fibrosis and Achromobacter xylosoxidans Infections | Zendy

Nathaniel Warner | Zendy; Luther A. Bartelt | Zendy; Anne M. Lachiewicz | Zendy; Kathleen Tompkins | Zendy; Melissa B. Miller | Zendy; Kevin Alby | Zendy; Melissa B. Jones | Zendy; Amy Carr | Zendy; Jose Alexander | Zendy; Andrew B. Gainey | Zendy; Robert Daniels | Zendy; AnnaKathryn Burch | Zendy; David E. Brown | Zendy; Michael Brownstein | Zendy; Faiqa Cheema | Zendy; Kristin E. Linder | Zendy; Ryan K. Shields | Zendy; Sarah Longworth | Zendy; David van Duin | Zendy

Open Access

Cefiderocol for the Treatment of Adult and Pediatric Patients With Cystic Fibrosis and Achromobacter xylosoxidans Infections

Author(s) -

Nathaniel Warner,

Luther A. Bartelt,

Anne M. Lachiewicz,

Kathleen Tompkins,

Melissa B. Miller,

Kevin Alby,

Melissa B. Jones,

Amy Carr,

Jose Alexander,

Andrew B. Gainey,

Robert Daniels,

AnnaKathryn Burch,

David E. Brown,

Michael Brownstein,

Faiqa Cheema,

Kristin E. Linder,

Ryan K. Shields,

Sarah Longworth,

David van Duin

Publication year - 2020

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciaa1847

Subject(s) - achromobacter xylosoxidans , cystic fibrosis , medicine , achromobacter , intensive care medicine , pseudomonas , bacteria , biology , genetics

Treatment options for Achromobacter xylosoxidans are limited. Eight cystic fibrosis patients with A. xylosoxidans were treated with 12 cefiderocol courses. Pretreatment in vitro resistance was seen in 3 of 8 cases. Clinical response occurred after 11 of 12 treatment courses. However, microbiologic relapse was observed after 11 of 12 treatment courses, notably without emergence of resistance.

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