Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response | Zendy

Kanagavel Murugesan | Zendy; Prasanna Jagannathan | Zendy; Tho D. Pham | Zendy; Suchitra Pandey | Zendy; Hector Bonilla | Zendy; Karen B. Jacobson | Zendy; Julie Parsonnet | Zendy; Jason R. Andrews | Zendy; Daniela Weiskopf | Zendy; Alessandro Sette | Zendy; Benjamin A. Pinsky | Zendy; Upinder Singh | Zendy; Niaz Banaei | Zendy

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Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response

Author(s) -

Kanagavel Murugesan,

Prasanna Jagannathan,

Tho D. Pham,

Suchitra Pandey,

Hector Bonilla,

Karen B. Jacobson,

Julie Parsonnet,

Jason R. Andrews,

Daniela Weiskopf,

Alessandro Sette,

Benjamin A. Pinsky,

Upinder Singh,

Niaz Banaei

Publication year - 2020

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciaa1537

Subject(s) - medicine , immunology , interferon , coronavirus , virology , respiratory system , respiratory disease , pandemic , covid-19 , disease , lung , infectious disease (medical specialty)

We investigated feasibility and accuracy of an interferon-γ release assay (IGRA) for detection of T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whole blood IGRA accurately distinguished between convalescent and uninfected healthy blood donors with a predominantly CD4+ T-cell response. SARS-CoV-2 IGRA may serve as a useful diagnostic tool in managing the coronavirus disease 2019 pandemic.

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